p63 is more sensitive and specific than 34βE12 to differentiate adenocarcinoma of prostate from cancer mimickers
نویسندگان
چکیده
OBJECTIVES Prostate cancer is the world's leading cause of cancer and the second cause of cancer-related death in men after lung cancer. Differentiation of prostate adenocarcinoma from benign prostate lesions and hyperplasia sometimes cannot be done on the basis of morphologic findings. Considering the fact that in the prostate adenocarcinoma there is no basal cell layer, basal cell markers can help to differentiate prostate adenocarcinoma from cancer mimickers. MATERIALS AND METHODS We studied 98 prostate biopsy blocks (40 adenocarcinoma and 58 benign lesions) for basal cell marker expression. RESULTS p63 and 34βE12 were negative in all prostate adenocarcinoma specimens, but all benign prostate hyperplasia and high grade intraepithelial neoplasia cases expressed them. CONCLUSION Basal cell markers can help to distinguish prostate adenocarcinoma from cancer mimickers.
منابع مشابه
p63 is more sensitive and specific than 34βE12 to differentiate adenocarcinoma of prostate from cancer mimickers
Objective(s): Prostate cancer is the world’s leading cause of cancer and the second cause of cancer-related death in men after lung cancer. Differentiation of prostate adenocarcinoma from benign prostate lesions and hyperplasia sometimes cannot be done on the basis of morphologic findings. Considering the fact that in the prostate adenocarcinoma there is no basal cell layer, basal cell markers ...
متن کاملUse of Immunohistochemistry as an Adjunct in the Diagnosis of Limited Adenocarcinoma of the Prostate Cancer
• The use of immunohistochemistry for basal cell markers and AMACR for the diagnosis of limited adenocarcinoma of the prostate should be used as an adjunct to the H&E diagnosis as there is false positive and negative staining with these markers. • Examples of labeling of prostate adenocarcinoma with basal cell markers include: aberrant scattered HMWCK staining of cancer cells; rarely the retent...
متن کاملProstate specific antigen staining intensity in prostatic adenocarcinoma correlates with serum prostate specific antigen , Bandar Abbas, Iran
Introduction: Prostatic adenocarcinoma is one the most common malignances and the second cause of death in males due to cancer. Prostate Specific Antigen (PZSA) serum level is the first marker to screen such patients. We aimed in this study, to assess the intensity of prostatic adenocarcinoma tissue staining with PSA staining method. Methods: In this corss-sectional study, prostatic adenocarcin...
متن کاملMonocarboxylate transporter 2 (MCT2) as putative biomarker in prostate cancer.
BACKGROUND Monocarboxylate transporter 2 (MCT2) is a transmembrane protein involved in the transport of monocarboxylates such as pyruvate and lactate. In a previous study we described overexpression of MCT2 in prostate carcinoma raising the hypothesis of using MCT2 as a possible biomarker in prostate cancer. With the present study we aimed to compare the pattern of expression of MCT2 and alpha-...
متن کاملAtypical adenomatous hyperplasia of the prostate mimicking adenocarcinoma lesion: case report and literature review.
The diagnosis of prostate cancer is challenging because of the existence of lesions that mimic adenocarcinoma. Such a lesion is atypical adenomatous hyperplasia (AAH) or adenosis, which represents a proliferation of crowded, small to medium glands with basal cell layer invariably present, but often inconspicuous on routine stains. The importance of the lesion lies in the potential for being mis...
متن کامل